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The web service registry approach to collaboration and reuse of web services has worked effectively in other endeavors.  A web service registry is at the heart of the cancer Biomedical Informatics Grid® (caBIG®), an information network funded largely by the National Cancer Institute, enabling members of the cancer community to share data and knowledge.\[[1|#footnote-1]\] The technical infrastructure of caBIG® is a ¿grid¿ of compatible web services enabled by a web service registry and core interoperability services known as caGrid.  The caGrid portal provides a view into the registry of services, which at the time of this writing contains 129 web services from 124 participating institutions.\[[2|#footnote-2]\]  The caGrid Index Service or registry allows members of the cancer community\-\-\-researchers, physicians, and patients\-\-\-to share information and knowledge.  For example, the grid allows physicians to locate and reuse complex analytical resources on the web, it enables researchers to query large data sets at multiple institutions in a single query, and it manages patient study calendars for clinical trials.  The caGrid registry infrastructure provides the core foundation for innovation.  Members of the cancer community can find what programmatic resources are available on the web, where they are located, and how to invoke these resources.  This transparency fosters the invention of new web services based on further analysis and research, the generation of new hypotheses, and the execution of research which accelerates the discovery of new strategies for the detection, diagnosis, treatment, and prevention of cancer.

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<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="151a47fb9db12e5a-33cc9175-4fbb4956-b1b68bf7-d4a6536c9b28c87a9fe608d8"><ac:parameter ac:name="">footnote-1</ac:parameter></ac:structured-macro>\[1\] National Cancer Institute, ¿About caBIG®,¿ National Cancer Institute, [https://cabig.nci.nih.gov/overview|https://cabig.nci.nih.gov/overview].

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<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="5770bbaf6bb916dd-551cefb2-4d984680-b94b8390-10fd3febf5f594ad3eb9a21c"><ac:parameter ac:name="">footnote-2</ac:parameter></ac:structured-macro>\[2\] National Cancer Institute, ¿caGrid Portal,¿ National Cancer Institute, [http://cagrid-portal.nci.nih.gov|http://cagrid-portal.nci.nih.gov/].

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<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="8861c4ef93704c0a-4288bc66-42e740bb-b1179045-a9799688cd3e506f070af7e9"><ac:parameter ac:name="">footnote-3</ac:parameter></ac:structured-macro>\[3\] Jiten Bhagat, Franck Tanoh, Eric Nzuobontane, Thomas Laurent, Jerzy Orlowski, Marco Roos, Katy Wolstencroft, Sergejs Aleksejevs, Robert Stevens, Steve Pettifer, Rodrigo Lopez, Carole Goble: ¿BioCatalogue: a universal catalogue of web services for the life sciences,¿ _Nucleic Acids Research_ (2010). doi:10.1093/nar/gkq394. Online at: [http://nar.oxfordjournals.org/cgi/content/full/gkq394|http://nar.oxfordjournals.org/cgi/content/full/gkq394].

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<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="04c68b1046a6cc73-583b3b9d-4f4b47e9-bf9abc1a-2e0f2d0707189b54d95f3208"><ac:parameter ac:name="">footnote-4</ac:parameter></ac:structured-macro>\[4\] University of Manchester, ¿Taverna -- open source and domain independent workflow system,¿ University of Manchester, UK, [http://www.taverna.org.uk|http://www.taverna.org.uk/].

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<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="86613f3cb05cc513-b2c68204-49b643e5-b880b1f2-559663ebe37edd9bb5441507"><ac:parameter ac:name="">footnote-5</ac:parameter></ac:structured-macro>\[5\] University of Manchester and the University  of Southhampton, ¿myExperiment Virtual Research Environment,¿&nbsp; [http://www.myexperiment.org|http://www.myexperiment.org/].

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<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="6428ebff703e3ab1-5d95b288-4162462c-bb858806-dfa3e9965a7d0fd6314e6d4b"><ac:parameter ac:name="">footnote-6</ac:parameter></ac:structured-macro>\[6\] The South Carolina Transfer and Articulation Center (SC TRAC) is a service center for transfer students, administrators, advisors, and faculty, designed to facilitate student transitions between South   Carolina¿s institutions of higher education.&nbsp; See [http://www.sctrac.org|http://www.sctrac.org/] for details.