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Background

The Atlanta Clinical and Translational Sciences Institute is a collaboration between Emory, the Morehouse School of Medicine and Georgia Tech.  ACTSI is one of 46 member institutions in the Clinical Translational and Sciences Awards consortium with the stated goal "to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research."

Project

Emory OIT will work with the Center for Comprehensive Informatics, ACTSI, and others to develop integration strategies for the several systems and technologies that will need to be coordinated in order to meet the objectives of the Institute.  These systems will include at least the following:

System

Description

LIMS

the Thermo Nautilus Laboratory Information Management System in use at Emory

CaTissue

a web-based biospecimen inventory and tracking tool that may be used by biospecimen resource facilities, regardless of the nature of biospecimen transactions that occur or the type of biospecimens involved in the transaction. Suite also supports integration with associated free-text surgical pathology reports (SPR) and discrete clinical and pathology annotations

CaArray

For background on DNA microarray data, analysis, and databases see the Wikipedia article.
caArray is an open-source, web and programmatically accessible array data management system. caArray guides the annotation and exchange of array data using a federated model of local installations whose results are shareable across the cancer Biomedical Informatics Grid (caBIG¿). caArray furthers translational cancer research through acquisition, dissemination and aggregation of semantically interoperable array data to support subsequent analysis by tools and services on and off the Grid. As array technology advances and matures, caArray will extend its logical library of assay management.
The initial generation of caArray (1.0) and subsequent point releases have provided the interface for sharing sample annotations along with the independent ability to upload and download data and programmatic data access via the MAGE-OM API and grid service. caArray 2 builds from this starting point by organizing the application around the natural workflow between investigators and the array labs that serve them, enhancing the user experience for storing and retrieving the data produced, and providing a simplified API for programmatic data query and access.

i2b2

 

CRAssist

Emory University's Clinical Trials Management System

OpenClinica

OpenClinica is a free, open source clinical trial software platform for Electronic Data Capture (EDC) clinical data management in clinical research. The software is web-based and designed to support all types of clinical studies in diverse research settings. From the ground up, OpenClinica is built on leading, independent standards to achieve high levels of interoperability and regulatory compliance. Its modular architecture and transparent, collaborative development model offer outstanding flexibility while supporting a robust, enterprise class, regulatory compliant, solution.

RedCAP

 

The project is exploring creating a proof-of-concept environment with deployments of each of these applications.

Use Cases

Federated Query

  • Example - Access aggregate existing patient information to decide the kinds of patients and data available for the study.
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